Often times we get so wrapped up in our busy lives that we trivialize pains we may feel or simply attribute any discomfort to gas or indigestion. While there are cases where that chilli dog you had at lunch may very well be the cause of that gnawing pain in your abdomen, there are times it may be something a little more serious. Here are five symptoms you should never ignore.

Spreading chest pain
If you experience pain moving from your shoulder or your jaw, that may indicate a blocked blood vessel, which stops blood from getting to your heart. Heart conditions typically mask themselves as discomfort, not pain.

“Don’t wait for pain,” cardiologist Jerome Cohen, MD said. “Heart patients talk about pressure. They’ll clench their fist and put it over their chest or say it’s like an elephant sitting on their chest.”

If you feel this discomfort you should consult a health professional immediately and take an aspirin.

Tingling foot pain
That pins-and-needles feeling in your feet and legs can be a sign you have diabetes

“In some people who don’t know they have diabetes, peripheral neuropathy could be one of the first signs,” Sharon Brangman, MD, FACP, spokeswoman for the American Geriatrics Society, said. “It’s a burning or pins-and-needles sensation in the feet or legs that can indicate nerve damage.”

Lower back pain
Chronic back pain isn’t only caused by uncomfortable shoes. A numbing sensation just above the buttocks and down to the legs may be indicative of a slipped or herniated disc. If this is the case, treatment typically involves exercises and stretches, with surgery needed in some cases.

Severe headache
A lot of people suffer from migraines, but a sharp localized headache can indicate a ruptured vessel. When patients complain they have “the worst headache of their life” we’ve learned in medical training that was a classic sign of a brain aneurysm, Brangman said. You should go immediately to the ER.

Leg warmth
If your leg is warm to the touch and you’re experiencing discomfort, you may have a blood clot. Deep vein thrombosis (DVT) affects about 2 million Americans a year and can be fatal. Blood clots can travel from your leg to your lungs and heart. If you’re experiencing this, do not massage the leg, as this could loosen the clot, allowing it to travel to other parts of your body.